THE INFLUENCE OF METRONIDAZOLE ON THE PHARMACOKINETIC PROFILE OF CHLORPROPAMIDE IN TYPE II DIABETIC PATIENTS

THE INFLUENCE OF METRONIDAZOLE ON THE PHARMACOKINETIC PROFILE OF CHLORPROPAMIDE IN TYPE II DIABETIC PATIENTS

Abstract:

The influence of metronidazole on the pharmacokinetic profile of chlorpropamide in Type II diabetic patients was examined. The quality of chlorpropamide and metronidazole tablets used in the study were pre -determined using official methods. The tablets complied with the BP (1988) requirements stated under the monograph for chlorpropamide and metronidazole tablets. Plasma levels of chlorpropamide were determined using colorimctric method (Martin et al, 1973). In addition, glucose levels were measured by standard glucose oxidase method (Martinek, 1964). Decreased levels of chlorpropamide were observed in concomitant administration of 250mg chlorpropamide with two 200mg metronidazole tablets(C) compared with administration of 250mg chlorpropamide tablet (control) (B). Insignificantly higher (pre and postprandial) levels of plasma glucose were observed in concomitant administration of metronidazole with chlorpropamide compared with administration of 250mg chlorpropamide alone. The pharmacokinetic parameters were calculated using semi – logarimathmic plots of concentration- time data for chlorpropamide. The area under the curve was calculated by trapezoidal rule. Administration of metronidazole concomitantly with chlorpropamide significantly affected some pharmacokinetic parameters of chlorpropamide such as ka, Cmax, Vd, AUG, and ti/2Ct. The elimination parameters, Lag time, and tmax as calculated in this study were not significantly affected.

THE INFLUENCE OF METRONIDAZOLE ON THE PHARMACOKINETIC PROFILE OF CHLORPROPAMIDE IN TYPE II DIABETIC PATIENTS