HEPATIC AND SERUM ENZYME CHANGES AFTER LINDANE POISONING IN RATS

HEPATIC AND SERUM ENZYME CHANGES AFTER LINDANE POISONING IN RATS

Abstract:

Acute and Chronic toxicity studies of lindane were carried out on rat using biochemical changes as indices of toxicity. The calculated LD50 was 25.4 mg per Kg body weight using the arithmetic method of Karber. The symptoms of toxicity were observed and scored by specific points according to the severity of symptoms of poisoning. Symptoms of toxicity observed include tremor, prostration, pallor, convulsion and death of the animal. Some serum biochemical parameters were analysed to evaluate the effect of lindane on the liver. The parameters includes Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), total protein (TP) and serum albumin (SA). ALT showed the most significant alteration throughout the study period. ALT is more sensitive to liver damage than AST. The other parameters showed no significant alteration. Histopathological examination of the liver indicates inflammation, congestion of the liver and fatty degeneration after prolonged exposure. The symptoms of poisoning were dose dependent in most cases

HEPATIC AND SERUM ENZYME CHANGES AFTER LINDANE POISONING IN RATS